Medical use[ edit ] Aspirin is used in the treatment of a number of conditions, including fever, pain, rheumatic feverand inflammatory diseases, such as rheumatoid arthritispericarditisand Kawasaki disease. Secondary headaches, meaning those caused by another disorder or trauma, should be promptly treated by a medical provider.
Contributors Over history, many compounds obtained from nature have been used to cure ills or to produce an effect in humans.
These natural products have been obtained from plants, minerals, and animals. In addition, various transformations of these and other compounds have led to even more medically useful compounds. During this semester, you will have an opportunity to isolate some pharmacologically active natural products and to synthesize other active Aspirin sythesis from suitable starting materials.
Analgesics are compounds used to reduce pain, antipyretics are compounds used to reduce fever. One popular drug that does both is aspirin.
The Merck Index, which is an encyclopedia of chemicals, drugs and biologicals, lists the following information under aspirin: Add 5 mL 0. H2SO4 use a dropper, H2SO4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves. Heat the flask gently on the steam bath for at least 10 minutes.
Allow the flask to cool to room temperature. If acetylsalicylic acid does not begin to crystallize out, scratch the walls of the flask with a glass rod. Cool the mixture slightly in an ice bath until crystallization is completed.
The product will appear as a solid mass when crystallization is completed. Add 50 mL of water and cool the mixture in an ice bath. Do not add the water until crystal formation is complete. Vacuum filter the product using a Buchner funnel. You can use some of the filtrate to rinse the Erlenmeyer flask if necessary.
Rinse the crystals several times with small portions 5 mL of cold water and air dry the crystals on a Buchner funnel by suction until the crystals appear to be free of solvent.
Test this crude product for the presence of unreacted salicylic acid using the ferric chloride test. Record the weight of the crude solid which probably contains water.
Filter the solution through a Buchner funnel to remove any insoluble impurities or polymers that may have been formed. Wash the beaker and the funnel with 5 to 10 mL of water.
Carefully pour the filtrate with stirring, a small amount at a time, into an ice cold HCl solution ca 3.Experiment 11 Synthesis and Analysis of Aspirin INTRODUCTION Aspirin is most widely sold over-the-counter drug.
It has the ability to reduce fever (an antipyretic), to reduce pain (an analgesic), and to reduce swelling, soreness, and . Aspirin’s conjugate base is also more stable compared to salol. It is easily hydrolyzed in alkaline medium because of high ionization constant derived from its acidic properties.
The H+ in aspirin is easily ionized due to the presence of O /5(6). aspirin to diminish inflammation is due to its inhibition of the synthesis of prostaglandins. Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group 4.
Aspirin is one of the most commonly used drugs in the world with approximately billion tablets1 being consumed annually.
Salicylic acid is a precursor of aspirin. Salicylic acid is found naturally in willow tree bark. Hippocrates, the father of. To further purify aspirin, one must know that both salicylic acid and aspirin are fairly soluble in warm water; however, salicylic acid is more soluble than aspirin in ethanol.
Therefore, a mixed solvent recrystallization technique is used where ethanol is the primary solvent and . SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place g ( mole) of salicylic acid in a mL Erlenmeyer flask.
Add 5 mL ( mole) of acetic anhydride, followed by 5 drops of conc. H 2 SO 4 (use a dropper, H 2 SO 4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves.