The cause was lack of vitamin B12 in his bloodstream, according to a case report from Harvard-affiliated Massachusetts General Hospital published in The New England Journal of Medicine. It could have been worse—a severe vitamin B12 deficiency can lead to deep depression, paranoia and delusions, memory loss, incontinence, loss of taste and smell, and more. The average adult should get 2.
Two patients were given 6 weeks of a daily supplement containing cyanocobalamin 0. Table 1 highlights the changes in both serum and CSF that resulted from vitamin B12 treatment. Treatment with IM hydroxocobalamin produced more significant increases than oral cyanocobalamin in the patients' CSF levels of vitamin B In group 1 patients with The symptoms and consequences of vitamin a deficiencythe authors speculate that zinc deficiency and its corresponding high levels of copper block the transport of B12 in the choroid plexus and therefore, the CSFsimilar to the effects of free radical chain reaction inducers like mercury, cadmium, and other neurotoxins.
Group 2 patients with organic affective syndromeall had exposures to toxic chemicals i. The authors speculate that these neurotoxins may block the entry of vitamin B12 into the brain, leading to CSF deficiency of the vitamin. In group 3 patients with postnatal depressionthe authors suggest that estrogens or estrogen-receptor binding chemicals e.
Sixteen Patients with Dementia and 13 Patients with Neurasthenia In another publication by the same authors, 16 geriatric patients aged 60 through 85 years with dementia or organic affective syndrome with coexisting dementia were assessed.
These patients did have signs and symptoms of polyneuropathy. Five patients that had normal serum levels and deficient CSF levels were given 3 months of treatment with parenteral hydroxocobalamin unstated dose. In a second group of 13 patients 29—50 years of age with neurasthenic symptoms, the vitamin B12 levels were assessed in both the serum and CSF.
All patients had normal liver function and no gross haematological abnormalities. These patients did have "soft" neurological signs of encephalopathy and neuropathy.
Without routine CSF analysis, the majority of these patients would not have been found to have a vitamin B12 deficiency. The authors concluded that all patients displaying organic mental symptoms should have their CSF levels of vitamin B12 assessed.
I am of the opinion that routine CSF measurements of vitamin B12 are impractical, expensive, and invasive. Perhaps another way of interpreting these results is to know that serum vitamin B12 levels within normal ranges might not reflect what is happening within the brain.
To encourage normal or even optimal CSF levels of vitamin B12, marked increases in serum levels of the vitamin might be achieved through IM administration. CSF levels of vitamin B12 did not correlate with severity of the dementia.
After oral methylcobalamin mcg per dayneither serum or CSF levels of vitamin B12 were significantly elevated. On the other hand, when the patients were given the same oral dose plus daily IM injections of methylcobalamin mcgmarked elevations occurred in both the serum and CSF compartments.
This study is compelling on two fronts. First, the serum vitamin B12 ranges used in this study are much higher than those reported in other publications.
Second, IM methylcobalamin was the only way to markedly increase both serum and CSF levels of vitamin B12 among the patients with dementia. Oral methylcobalamin did not appreciably increase serum and CSF levels of vitamin B All of the patients were 16 years of age and older and not on any medication.
They were taking a variety of supplements such as vitamins, minerals, and unsaturated fats. All patients, through trial and error, were given injections of hydroxocobalamin to establish ideal doses of the vitamin doses ranged from mcg 4 times each week to mcg per day.
Serum vitamin B12 levels were drawn when patients felt the greatest sense of well-being and were also drawn after the injections were discontinued for 5 to 7 days. Patients also completed the MMPI numerous times duration of the trial period.
The highest serum vitamin B12 levels average: With lower serum vitamin B12 levels average: The author concluded that vitamin B12 dependency disorders are common and neglected by the medical profession because: Two Patients with Sleep-Wake Disorders Two adolescent patients with persistent sleep-wake schedule disorders responded to treatment with oral methylcobalamin.
A year-old girl had delayed sleep phase syndrome DSPS and was similarly unable to attend school despite numerous medication trials. Both patients did not have any laboratory or clinical evidence of vitamin B12 deficiency or hypothyroidism. Improvement of their sleep-wake schedule disorders appeared immediately after the administration of high doses micrograms per day of oral methylcobalamin.
Serum concentrations of vitamin B12 during the treatment period were in the high range of normal or above normal.The kidneys and liver serve vital functions for overall wellness of the body. The kidneys remove waste from the body to prevent toxicity of other organs.
I wrote an article online about the dangers of Vitamin D deficiency and thought it would be fitting for this site. Never try to diagnose yourself. Read about osteoporosis treatment options, medication, causes, symptoms, signs, diagnosis, prevention (diet, weight-bearing exercise), risk factors (family history), and research.
Osteoporosis is a condition marked by decreased bone density and strength, resulting in fragile bones.
Vitamin D and its active metabolite 1,dihydroxyvitamin D (1,25(OH)2D) have classical actions on calcium balance and bone metabolism (1) insufficient 1,25(OH)2D leads to inadequate absorption of calcium and phosphate which results in secondary hyperparathyroidism and lack of new bone. 1 Vitamin D deficiency results in chronic fatigue and multi-system symptoms Author: Dr. med. Anna Dorothea Hoeck, MD, Mariawaldstr. 7, Cologne, Germany. Read about osteoporosis treatment options, medication, causes, symptoms, signs, diagnosis, prevention (diet, weight-bearing exercise), risk factors (family history), and research. Osteoporosis is a condition marked by decreased bone density and strength, resulting in fragile bones.
There are many causes for vitamin B12 deficiency. Surprisingly, two of them are practices often undertaken to improve health: a vegetarian diet and weight-loss surgery.
Why Vitamin D? Home.
VITAMIN D: Deficiency, Diversity and Dosage. by Andrew W. Saul (Reprinted with permission from the Journal of Orthomolecular Medicine, ; Vol. 18, Numbers 3 and 4, p. ) "Vitamin D deficiency is a major unrecognized health problem.". 2 Vitamin D deficiency is a hidden disorder of high frequency Vitamin D deficiency is by no means rare (3,).
In particular, highly gifted and engaged.